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KMID : 1011320180100010009
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Journal of Pharmacoepidemiology and Risk Management
2018 Volume.10 No. 1 p.9 ~ p.15
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Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome
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Koh Young-Il
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Abstract
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Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare but serious adverse drug reaction, which is characterized by skin rashes, blood eosinophilia, atypical lymphocytosis, and internal organ involvements, such as lymphadenopathy, hepatitis, nephritis, pneumonitis, or carditis. Common culprit drugs include anticonvulsants such as carbamazepine and lamotrigine, allopurinol, dapsone, vancomycin, anti-tuberculosis drugs, cephalosporin, sulfamethoxazole, and nonsteroidal anti-inflammatory drugs. However, any drugs are possible to induce DRESS syndrome. Unlike other drug allergies, latency periods are longer, ranging from 1 to 8 weeks, and it takes longer times, ranging between 1 and 3 months, for clinical manifestations to be resolved even after withdrawal of the culprit drugs. Mortality is known to be about 10%. Thus, the understanding of DRESS syndrome is important in the field of adverse drug reactions.
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KEYWORD
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DRESS syndrome, Drug allergy, Severe cutaneous adverse reaction
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